[NetBehaviour] Viral Fossil Brought Back to Life.
marc.garrett at furtherfield.org
Fri Nov 3 13:19:04 CET 2006
Viral Fossil Brought Back to Life.
By Martin Enserink
ScienceNOW Daily News
In a controversial study, researchers have resurrected a retrovirus that
infected our ancestors millions of years ago and now sits frozen in the
human genome. Published online by Genome Research this week, the study
may shed new light on the history of these genomic intruders, as well as
their role in tumors. Although this particular virus, dubbed Phoenix, is
a wimpy one, some argue that resuscitating any ancient virus is
inherently risky and that the study should have undergone stricter reviews.
Retroviruses have the ability to make DNA copies of their RNA genomes
and incorporate these into the host's genome. If this happens in a germ
cell, the copy can be passed on to future generations. Indeed, the human
genome is littered with the remnants of such human endogenous
retroviruses (HERVs) (ScienceNOW, 29 September 2004). So far,
researchers had been unable to recover a complete, functional HERV from
a human genome however; part of the reason, they assumed, was that
mutations accumulated over the millennia had rendered such viruses
A team led by Thierry Heidmann at the Institut Gustave Roussy in
Villejuif, France, near Paris, decided to try to awaken the ancestor of
an entire family of HERVs called HERV-K(HML2). To "correct" for
mutations, the researchers took dozens of known HERV-K(HML2) sequences
and aligned them to create a so-called "consensus" sequence. Then they
converted this information into a complete viral genome.
More information about the NetBehaviour